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KMID : 1161420130160030268
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Journal of Medicinal Food
2013 Volume.16 No. 3 p.268 ~ p.271
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In Vivo Genotoxicity and Oxidative Stress Evaluation of an Ethanolic Extract from Piquia (Caryocar villosum) Pulp
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Almeida Mara Ribeiro
Aissa Alexandre Ferro
Gomes Tarsila Daysy Ursula Hermogenes
Darin Joana D’Arc Castania
Chiste Renan Campos
Mercadante Adriana Zerlotti
Antunes Lusania Maria Greggi
Bianchi Maria Lourdes Pires
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Abstract
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In this study, the ethanolic extract obtained from piquia pulp was assessed for genotoxicity and oxidative stress by employing the micronucleus test in bone marrow and peripheral blood cells in addition to comet, thiobarbituric-acid?reactive substances (TBARS), and reduced glutathione assays in the liver, kidney, and heart. Additionally, phytochemical analyses were performed to identify and quantify the chemical constituents of the piquia extract. Wistar rats were treated by gavage with an ethanolic extract from piquia pulp (75?mg/kg body weight) for 14 days, and 24?h prior to euthanasia, they received an injection of saline or doxorubicin (15?mg/kg body weight, intraperoneally). The results demonstrated that piquia extract at the tested dose was genotoxic but not mutagenic, and it increased the TBARS levels in the heart. Further studies are required to fully elucidate how the properties of ethanolic extract of piquia pulp can affect human health.
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KEYWORD
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carotenoids, comet assay, in vivo, micronucleus test, phenolic compounds, Wistar rats
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